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Target intelligence / Profile preview
Cancer Cell (Tumor-Selective Lysis via Viral Replication) (Oncolytic Virus Therapy)
- Target
- Oncolytic Virus Therapy
- Molecular classification
- Virus, Gene therapy vector
01
Overview
The target "cancer cell (tumor-selective lysis via viral replication)" refers to the use of oncolytic viruses—viruses engineered or naturally able to selectively infect, replicate within, and lyse cancer cells while sparing normal tissues. This approach exploits the unique vulnerabilities of tumor cells, such as defects in antiviral responses and dysregulated signaling pathways, allowing for preferential viral replication and subsequent destruction of malignant cells. The process releases new viral particles that can infect neighboring cancer cells, amplifying the therapeutic effect and stimulating an anti-tumor immune response.
- Other names
- Oncolytic VirusesTumor-Selective Viral ReplicationVirotherapyCancer Cell Lysis by Virus
02
Mechanism of action
Selective infection and replication within tumor cells, leading to lysis and release of viral particles and tumor antigens.
03
Biological functions
Cell deathImmune response stimulationTumor lysisViral replication
04
Disease associations
Cancer
05
Safety considerations
Off-target effects on normal cellsPotential for viral recombination and evolutionImmune response against the virusSuboptimal efficacy compared to preclinical modelsDelivery challenges to reach all tumor cellsDevelopment of resistance
06
Biomarkers
Tumor cell tropism markers for specific virusesViral replication markers within tumorImmune response markers (e.g., T cell infiltration, cytokine levels)
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