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Target intelligence / Profile preview
Cancer Cell (via Oncolytic Virus-Induced Lysis)
- Molecular classification
- Cell
01
Overview
"Cancer cell (via oncolytic virus-induced lysis)" refers broadly to any malignant cell that can be selectively infected and destroyed through direct cytolytic action by an oncolytic virus. This process leverages both intrinsic weaknesses in cancer biology and engineered features within the viruses themselves, resulting not only in physical destruction but also potent stimulation of anti-tumor immunity—a dual effect central to modern virotherapies[1][3][8].
- Other names
- Malignant Cell (OV-mediated lysis)Tumor Cell (Oncolytic Virus Target)
02
Mechanism of action
Selective infection → Viral replication → Direct lysis + Immunogenic cell death
03
Biological functions
Cell deathCell proliferationAntiviral defense (defective)Tumor growth
04
Disease associations
Cancer
05
Safety considerations
Off-target viral infectionImmune-related adverse eventsPre-existing immunity against the virusTumor lysis syndrome
06
Interacting drugs
Oncolytic Viruses
2 more in the full profile.
07
Biomarkers
Viral entry receptor expressionType I interferon pathway activityp53 statusPTEN status
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