Cancer Cell Antioxidant Systems

Cancer cell antioxidant systems refer to the network of molecules and enzymes that cancer cells use to maintain redox homeostasis by neutralizing reactive oxygen species (ROS). These systems are often upregulated in cancer, enabling tumor cells to survive high oxidative stress, resist apoptosis, and develop resistance to therapies. This adaptive response is known as "redox reprogramming," where both ROS and antioxidants are maintained at elevated levels. Key components include enzymatic antioxidants like superoxide dismutases (SODs), catalase (CAT), glutathione peroxidases (GPXs), peroxiredoxins (PRDXs), and the thioredoxin system. Non-enzymatic antioxidants include glutathione (GSH), vitamins C/E, melatonin, and ubiquinone. The Nrf2/KEAP1 signaling axis is a major regulatory pathway. Targeting these systems can sensitize tumors to therapy.

Other names

Tumor Cell Antioxidant SystemsCancer Redox Homeostasis Mechanisms

Inhibition of antioxidant enzymes or pathways to induce ROS accumulation and cell death. Modulation of Nrf2 signaling.