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Target intelligence / Profile preview
Cancer Cell DNA
- Molecular classification
- DNA, Genetic Material
01
Overview
Cancer cell DNA refers to the genetic material within cancerous cells that has undergone mutations or structural changes, leading to uncontrolled cell growth and division. These alterations in DNA are central to the transformation of normal cells into cancer cells and drive many of the hallmarks of cancer, such as unchecked proliferation, evasion of apoptosis (programmed cell death), and genomic instability. Therapies increasingly target features unique to cancer cell DNA, such as defective repair pathways or specific mutated sequences.
02
Mechanism of action
Various mechanisms depending on the drug. PARP inhibitors target DNA repair pathways. Chemotherapy drugs induce DNA damage. Genome editing tools modify specific DNA sequences.
03
Biological functions
Genetic Information StorageCell Growth RegulationCell DivisionApoptosis RegulationDNA Repair
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of genome editingDevelopment of resistance to chemotherapySecondary malignancies induced by DNA-damaging therapies
06
Interacting drugs
PARP inhibitors
2 more in the full profile.
07
Biomarkers
BRCA1/2 mutationsMicrosatellite instability (MSI)Tumor Mutational Burden (TMB)
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