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Target intelligence / Profile preview
Cancer Cell Glucose Deprivation Tolerance (GD Tolerance)
- Target
- GD Tolerance
- Molecular classification
- Metabolic adaptation, Cellular stress response, Tumor microenvironment adaptation
01
Overview
Cancer cell glucose deprivation tolerance describes the ability of cancer cells to survive and adapt to conditions of low glucose. This involves metabolic reprogramming, enhanced antioxidant defenses, and activation of stress response pathways to maintain ATP levels and mitigate oxidative stress, ultimately contributing to drug resistance and tumor progression.
- Other names
- Glucose starvation resistanceGlucose deprivation adaptationLow glucose survival in cancer cells
02
Mechanism of action
N/A - This is a cellular phenotype, not a single molecule.
03
Biological functions
Cell survivalMetabolic reprogrammingStress responseAntioxidant defenseATP maintenance
04
Disease associations
CancerDrug resistanceTumor progression
05
Safety considerations
Potential for off-target effects of metabolic inhibitorsDevelopment of resistance to therapies targeting glucose metabolismComplex interplay of metabolic pathways requiring careful consideration for combination therapies
06
Interacting drugs
Glucose metabolism inhibitors
4 more in the full profile.
07
Biomarkers
Expression levels of GLUT1, fatty acid oxidation enzymes, antioxidant enzymesROS levelsATP levels under glucose deprivationActivity of AMPK, tyrosine kinases
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