Cancer cell immune evasion machinery

Cancer cell immune evasion machinery describes a complex biological process rather than a discrete therapeutic target. It encompasses multiple mechanisms, pathways, and molecular components that cancer cells use to evade immune detection, including antigen presentation downregulation (MHC-I, β2-microglobulin), immune checkpoint pathways (PD-1/PD-L1, CTLA-4), metabolic alterations and immunosuppressive cell recruitment, T cell exhaustion and inhibition, and extracellular matrix remodeling and physical barriers to immune infiltration. To obtain structured target information, individual molecular components within this machinery would need to be specified.