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Cancer cell lysis via selective viral replication dependent on cellular thymidine kinase
- Molecular classification
- Enzyme (Thymidine Kinase 1), Oncolytic virus
01
Overview
This therapeutic strategy targets cancer cells by exploiting their elevated thymidine kinase 1 (TK1) activity to enable selective replication of engineered oncolytic viruses. The approach leads to the lysis of tumor cells while sparing normal tissues.
02
Mechanism of action
Engineered virus replicates selectively where cellular TK activity supports efficient DNA synthesis; leads to targeted tumor cell death
03
Biological functions
DNA synthesisCell proliferationCell deathAntitumor immunity
04
Disease associations
Cancer
05
Safety considerations
Off-target viral replicationImmune response to virusPotential for insertional mutagenesis
06
Biomarkers
Plasma TK1 levelsTissue TK1 levels
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