Cancer cell oncolysis

"Cancer cell oncolysis" describes the process by which cancer cells are destroyed, typically by the rupture (lysis) of their membranes. In the context of modern cancer therapy, it is often discussed with reference to **oncolytic virus therapy**: genetically engineered or naturally occurring viruses are designed to selectively infect and replicate in cancer cells, causing them to burst and die. This primary lytic effect can also stimulate an immune response against the tumor by exposing tumor-specific antigens. Oncolysis is not a specific protein, gene, or receptor, but is an important therapeutic mechanism and endpoint in cancer treatment.

Other names

oncolysiscancer cell lysistumor cell lysiscell lysis (non-specific)

Direct viral lysis of cancer cells\nIndirect activation of the immune response via release of tumor antigens\nAlteration of the tumor microenvironment to facilitate cell death and immune infiltration