Cancer Cell Surface Antigen (CCSA)

Cancer cell surface antigens are molecules expressed on the surface of cancer cells that can be recognized by the immune system. These antigens can be tumor-specific (TSA) or tumor-associated (TAA) and serve as targets for immunotherapy and diagnostic biomarkers. They play a critical role in immune recognition of cancer cells and can be exploited for targeted therapies like monoclonal antibodies and CAR-T cells. Examples include CD19, EGFR, and integrin β7. Careful selection of target antigens is crucial to minimize off-target toxicity.

Other names

Tumor-Specific AntigenTumor-Associated AntigenTSATAA

Binding of antibodies or CAR-T cells to the antigen leading to tumor cell lysis, apoptosis, or growth inhibition. Small molecule inhibitors block the function of specific antigens like growth factor receptors.