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Target intelligence / Profile preview
Cancer-specific plectin
- Molecular classification
- Cytoskeletal protein, Scaffolding protein
01
Overview
Cancer-specific plectin (CSP) is a pro-tumorigenic protein variant of plectin that is selectively expressed on the cell surface of various major cancers. Unlike normal plectin, which is typically an intracellular cytoskeletal scaffolding protein, CSP exhibits aberrant localization to the plasma membrane in tumor cells. It promotes proliferation, migration, and invasion of tumor cells, driving metastatic potential. Therapeutic targeting of CSP with monoclonal antibodies or small molecule inhibitors shows promise in reducing tumor growth and metastasis.
- Other names
- CSPPlectin variantPLEC
02
Mechanism of action
Antibody-mediated cytotoxicity; Inhibition of FAK/MAPK/Erk/PI3K-Akt pathways
03
Biological functions
Cell adhesionCell migrationSignal transductionTumorigenesisMetastasis
04
Disease associations
CancerOvarian cancerPancreatic ductal adenocarcinomaLung adenocarcinomaHead and neck squamous cell carcinoma
05
Safety considerations
Potential off-target effects on normal tissues expressing plectinDevelopment of resistance to targeted therapies
06
Interacting drugs
Monoclonal antibodies against CSP
1 more in the full profile.
07
Biomarkers
CSP expression on cell surfaceCSP+ cells in tumor
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