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Cancer Stem Cell

Molecular classification: Cellular subpopulation

Overview

Cancer stem cells represent a highly influential subpopulation within tumors responsible for self-renewal capacity and driving both therapeutic resistance and metastatic spread. Their identification relies on specific surface markers shared with normal stem/progenitor cells. Ongoing research focuses on developing targeted therapies—including advanced immunotherapies—to eradicate this population in order to improve long-term patient outcomes across various cancers.

Other names: CSCTumor-initiating cell

Mechanism of action

Inhibition of CSC signaling pathways; targeting CSC surface antigens

Biological functions

Self-renewalDifferentiationTumorigenesisTherapy resistanceMetastasis

Disease associations

CancerTumor relapseMetastasisTherapy resistance

Safety considerations

Off-target effects of CSC-targeted therapiesDevelopment of resistance to CSC-targeted therapiesPotential for disrupting normal stem cell function

Biomarkers

CD133 (PROM1)CD44ALDH1A1CD34CD24EpCAM (Epithelial Cell Adhesion Molecule)

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