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Target intelligence / Profile preview
Cancer Stem Cell Pathway (CSC Pathway)
- Target
- CSC Pathway
- Molecular classification
- Signaling pathway, Regulatory network
01
Overview
The "cancer stem cell pathway" encompasses several interrelated intracellular signaling cascades—most notably Wnt/β-catenin, Notch, Hedgehog, JAK/STAT, NF‑κB—that maintain the unique properties of cancer stem cells. These networks are central targets for next-generation anti-cancer strategies aimed at improving long-term patient outcomes by eradicating resistant tumor-driving cells.
- Other names
- Cancer Stemness PathwayCSC Signaling Network
02
Mechanism of action
Disruption of intracellular signaling cascades that maintain cancer stem cell properties.
03
Biological functions
Self-renewalDifferentiationTumor initiationMetastasisDrug resistanceCell survivalCell proliferationAngiogenesisImmune modulation
04
Disease associations
CancerDrug resistanceMetastasisTumor recurrence
05
Safety considerations
Off-target effectsDevelopment of resistanceImmune-related adverse eventsPotential for affecting normal stem cell function
06
Interacting drugs
Wnt inhibitors
7 more in the full profile.
07
Biomarkers
Expression levels of pathway components (e.g., Wnt, Notch, Hedgehog ligands/receptors)Expression levels of pluripotency transcription factors (e.g., OCT4, Sox2, Nanog)CSC surface markers (e.g., CD44, CD133)
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