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Target intelligence / Profile preview
Candida albicans (C. albicans)
- Target
- C. albicans
- Molecular classification
- Fungus, Ascomycota, Saccharomycetes
01
Overview
Candida albicans is an adaptable fungal pathogen capable of causing superficial to severe systemic disease when host-microbe balance breaks down due to environmental changes or immune suppression. It is a common commensal fungus that colonizes the oropharyngeal cavity, gastrointestinal and vaginal tract. The various clinical manifestations range from localized, superficial mucocutaneous disorders to invasive diseases that involve multiple organ systems and are life-threatening. C. albicans is commonly used as a model organism for fungal pathogens and grows both as yeast and filamentous cells.
- Other names
- Monilia albicans
02
Mechanism of action
Azoles: Inhibit ergosterol synthesis; Polyenes: Bind to ergosterol, disrupting cell membrane integrity; Echinocandins: Inhibit β-1,3-glucan synthase, disrupting cell wall synthesis
03
Biological functions
CommensalismMorphological switchingBiofilm formationSecretion of hydrolytic enzymes
04
Disease associations
Thrush/oral candidiasisVulvovaginal candidiasisInvasive/systemic candidiasisCandidemiaEndocarditisBiofilm-associated infections
05
Safety considerations
Antifungal resistanceDrug-drug interactionsNephrotoxicity (amphotericin B)Hepatotoxicity (azoles)Invasive candidiasis in immunocompromised patients
06
Interacting drugs
Azoles (e.g., fluconazole, voriconazole)
2 more in the full profile.
07
Biomarkers
β-D-glucanMannanAnti-Candida antibodiesCandida DNA
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