Canis familiaris allergen 2 (Can f 2)

Canis familiaris allergen 2 (Can f 2) is a major protein allergen produced by the domestic dog, primarily found in saliva and dander [1, 2]. It belongs to the lipocalin family, a group of small, secreted proteins that typically transport hydrophobic molecules such as pheromones or vitamins [6, 14]. In sensitized individuals, Can f 2 triggers Type I hypersensitivity reactions by cross-linking IgE on mast cells and basophils, leading to the release of inflammatory mediators [3, 4]. This process is a significant driver of clinical conditions such as allergic rhinitis and asthma, with Can f 2 sensitization often associated with increased bronchial inflammation [2, 5]. In the pharmaceutical context, Can f 2 is a key component of allergen-specific immunotherapy (AIT), where controlled exposure to the allergen is used to desensitize the immune system and induce long-term tolerance [4, 5]. While AIT is a primary therapeutic approach, it carries the risk of inducing systemic allergic reactions or anaphylaxis, requiring careful clinical monitoring [4].

Other names

Dog 2Can d 2Canis familiaris allergen 2

Induction of immunological tolerance by shifting the immune response from a Th2-mediated allergic profile to a Treg and Th1-mediated profile, accompanied by the production of blocking IgG4 antibodies.