Cannabinoid receptor 1 and cannabinoid receptor 2 (CB1, CB2)

Cannabinoid receptor 1 and cannabinoid receptor 2 are members of the G protein-coupled receptor family that mediate the effects of endogenous cannabinoids (anandamide, 2-AG), phytocannabinoids (THC, CBD), and synthetic cannabinoids. Both receptors are present in the skin, with complementary patterns in epidermal keratinocytes, sebaceous glands, hair follicles, mast cells, and immune cells. They regulate skin barrier formation, keratinocyte growth, immune and inflammatory responses, and sebum production. Dysregulation of these receptors is implicated in various dermatological disorders such as atopic dermatitis, psoriasis, acne, and certain tumors. Modulation of these receptors is being explored therapeutically for inflammatory and proliferative skin diseases

Other names

CB1 receptorCB1RCB2 receptorCB2Rcannabinoid receptorsendocannabinoid receptors

Agonism or antagonism of CB1/CB2 receptors to modulate inflammatory responses. Inhibition of keratinocyte proliferation or induction of apoptosis in pathological states. Modulation of sebum/lipid production via sebocytes.