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Target intelligence / Profile preview
Cannabinoid receptor type 2 (CB₂)
- Target
- CB₂
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The cannabinoid receptor type 2 (CB2) is a G protein-coupled receptor (GPCR) predominantly expressed in immune system tissues. It modulates immune cell function, offering potential for anti-inflammatory effects without the psychoactivity associated with CB1 activation. CB2 is also implicated in pain management, neurodegenerative diseases, epilepsy, and addiction.
02
Mechanism of action
Primarily couples to Gi/o proteins leading to inhibition of adenylate cyclase activity; can also interact with Gs or Gq/11 depending on cell/tissue context.
03
Biological functions
Immune regulationInflammatory responsePain modulationNeuroprotectionSignal transduction
04
Disease associations
InflammationNeurodegenerative diseaseNeuropathic painEpilepsyAddictionAttention deficit hyperactivity disorder (ADHD)Insomnia
05
Safety considerations
Potential for off-target effectsTherapeutic challenges in selectively targeting CB2 without affecting CB1Limited brain expression under normal conditions may affect drug delivery
06
Interacting drugs
2-arachidonoylglycerol (2‑AG)
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