Canonical Human Protein Targets

The term "Canonical Human Protein Targets" refers to the broad collection of human proteins that are recognized as valid points of therapeutic intervention rather than a specific, individual molecular target (Santos et al., 2017, Nature Reviews Drug Discovery). This collective group includes approximately 600 to 1,500 proteins that are currently targeted by FDA-approved drugs, and a larger set of "druggable" proteins estimated to be around 3,000 (Finan et al., 2017, Science Translational Medicine). Common families within this set include G protein-coupled receptors, enzymes (such as kinases and proteases), ion channels, and nuclear receptors (The Human Protein Atlas). Because this entry represents a general category or a database classification rather than a single biological entity, it does not have a specific mechanism of action, biological function, or set of interacting drugs. For a detailed analysis, a specific protein target (e.g., "Tumor necrosis factor" or "Epidermal growth factor receptor") must be identified.

Other names

Human Proteome TargetsDruggable Human GenomeTherapeutic Protein Targets

Not applicable