Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cap Binding Complex (CBC)
- Target
- CBC
- Molecular classification
- Protein Complex, RNA-binding protein
01
Overview
The cap binding complex (CBC) is a highly conserved, essential heterodimeric protein complex in eukaryotes that binds to the 5' cap structure of nascent messenger RNA (mRNA). This interaction is crucial for multiple steps in gene expression, including mRNA processing, export, surveillance, and translation initiation. CBC consists of two main subunits: CBP20 (Cap Binding Protein 20; also known as NCBP2) and CBP80 (Cap Binding Protein 80; also known as NCBP1). After transcription, CBC binds cotranscriptionally to nascent pre-mRNAs at their capped 5′ end and remains associated through nuclear processing events until export into the cytoplasm. Upon entry into the cytoplasm or after pioneer round(s) of translation, CBC is replaced by eIF4E/eIF4F on most mature mRNAs.
- Other names
- NCBP1/NCBP2 complex
02
Mechanism of action
Inhibition of CBC binding to mRNA cap structure (theoretical)
03
Biological functions
mRNA processingNuclear exportmRNA protection from degradationTranslation initiationNonsense-mediated decay
04
Safety considerations
Potential for off-target effects on global mRNA metabolismDisruption of essential cellular processes
Beyond the preview
Go deeper on Cap Binding Complex (CBC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cap Binding Complex (CBC).