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Target intelligence / Profile preview
CAP-Gly domain-containing linker protein 1 (CLIP1)
- Target
- CLIP1
- Molecular classification
- Other (Microtubule-associated protein)
01
Overview
CAP-Gly domain-containing linker protein 1 (CLIP1), also known as CLIP-170, is a microtubule-associated protein that binds to the plus ends of microtubules and regulates microtubule cytoskeleton dynamics[2][4][7]. It promotes microtubule growth and bundling, and facilitates the attachment of endocytic vesicles and endosomes to microtubules, playing essential roles in intracellular vesicle trafficking and macropinocytosis[1][3][5][6]. CLIP1 is highly expressed in Reed-Sternberg cells of Hodgkin disease and has been implicated in neuronal regulation and neurodevelopmental disorders[1][3][6]. It interacts with several proteins, including IQGAP1, mTOR, and PAFAH1B1, mediating various cell signaling and transport processes[2]. No direct drug interactions or targeted therapeutics are currently reported for CLIP1.
- Other names
- CLIP-170CLIP170CYLN1RSNRestinCytoplasmic linker protein 170 alpha-2Cytoplasmic linker protein 1Reed-Sternberg intermediate filament-associated proteinCytoplasmic linker protein CLIP-170
02
Biological functions
Regulation of microtubule dynamicsMicrotubule bindingPromotion of microtubule growthMicrotubule bundlingVesicle traffickingEndosome traffickingMacropinocytosisKinetochore-microtubule attachment
03
Disease associations
Cancer (notably Hodgkin disease and Reed-Sternberg cells)Autosomal recessive non-syndromic intellectual disabilitySeckel syndrome
04
Biomarkers
Marker for Reed-Sternberg cells and dendritic cells in Hodgkin disease
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