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CAP-Gly domain-containing linker protein 3 (CLIP3)
- Target
- CLIP3
- Molecular classification
- Other (Microtubule-associated scaffold/cytoskeletal linker protein)
01
Overview
CAP-Gly domain-containing linker protein 3 (CLIP3) is a member of the cytoplasmic linker protein 170 family, characterized by a cytoskeleton-associated protein glycine-rich (CAP-Gly) domain. CLIP3 acts as a cytoplasmic linker protein involved in binding microtubules, especially at their plus-ends, and facilitating their interaction with cellular organelles and the plasma membrane. It participates in TGN-endosome trafficking, modulates the localization of the AKT kinase family to the cell membrane (with consequences for glucose transport in adipocytes), and has a regulatory role in T cell apoptosis by connecting tubulin to lipid raft components. Multiple transcript variants may exist due to alternative splicing.
- Other names
- CLIP3CLIPR59CLIP-170-related 59 kDa proteinCLIPR-59RSNL1Cytoplasmic linker protein 170-related 59 kDa proteinRestin-like 1
02
Biological functions
Microtubule bindingMicrotubule plus-end bindingScaffold protein for membrane localization of phosphorylated protein kinase B (AKT)Mediates interaction of microtubules with organelles and plasma membraneRegulates T cell apoptosisInvolved in intracellular vesicular trafficking and TGN-endosome dynamicsFacilitates glucose transport in adipocytes
03
Disease associations
Other (Reported associations: conjunctival pigmentation, patent foramen ovale)Potential indirect roles in signaling pathways (e.g., TNF signaling, neurotrophin receptor signaling), but not established as a primary disease driver
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