CAP-Gly domain containing linker protein family member 4 (CLIP4)

CAP-Gly domain containing linker protein family member 4 (CLIP4) is a human protein encoded by the CLIP4 gene, characterized by two CAP-Gly (cytoskeleton-associated protein glycine-rich) domains and numerous ankyrin repeats[1][5]. These domains suggest a role in the regulation of microtubule dynamics and protein-protein interactions. CLIP4 is most highly expressed in the thyroid, adrenal cortex, atrioventricular node, and muscle tissues[1]. Although not canonically classified as a therapeutic target such as a receptor, enzyme, or transporter, CLIP4 has emerging importance in oncology research, particularly as a potential tumor suppressor or biomarker; its downregulation and promoter hypermethylation are linked to breast and colon cancers. There are no known drugs that directly target CLIP4, and it has not been implicated as a direct therapeutic target or drug mechanism site. Functional studies associate it with cytoplasmic microtubule organization and possible interactions with other microtubule-associated proteins such as MAPRE1, MAPRE2, and MAPRE3[1].

Other names

CLIP4RSNL2CAP-Gly domain containing linker protein family member 4Restin-like protein 2