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Capecitabine Metabolite-Induced Local Toxicity
- Molecular classification
- Metabolic Disorder, Drug Toxicity
01
Overview
Capecitabine metabolite-induced local toxicity refers to tissue-specific adverse effects, primarily hand-foot syndrome (HFS) and mucositis, caused by the accumulation of active metabolites of capecitabine, particularly 5-fluorouracil (5-FU), in tissues with high thymidine phosphorylase (TP) activity. This localized drug activation leads to cellular damage and inflammation.
- Other names
- Hand-Foot Syndrome (HFS) caused by Capecitabine5-FU induced local toxicityCapecitabine-associated mucositis
02
Mechanism of action
Localized accumulation of 5-FU leading to GSDME-mediated pyroptosis and cellular damage in tissues with high thymidine phosphorylase activity.
03
Biological functions
Cell deathInflammationEnzyme activation (localized)
04
Disease associations
Cancer (treatment-related adverse effect)Drug-induced toxicity
05
Safety considerations
Hand-foot syndrome (HFS)Gastrointestinal mucositisSevere liver injury (rare)
06
Interacting drugs
Capecitabine
2 more in the full profile.
07
Biomarkers
Thymidine phosphorylase (TP) expression levelsGSDME expression
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