Capicua transcriptional repressor pseudogene 17 (CICP17)

Capicua transcriptional repressor pseudogene 17 (CICP17) is an annotated human pseudogene similar in sequence to the functional capicua transcriptional repressor (CIC) gene but does not encode a functional protein product[1][7]. Pseudogenes are evolutionary remnants of genes that have lost their capacity to produce a functional protein due to disabling mutations, frameshifts, or other genomic alterations[7]. While some pseudogenes have been shown to act as regulatory non-coding RNA or to modulate gene expression, there is no published evidence of such a function for CICP17[1][7]. It is not a recognized therapeutic target, nor is it linked to human diseases as a causative gene. CICP17 should not be confused with the functional gene capicua (CIC), which acts as a transcriptional repressor involved in cancer and neurodevelopmental disorders[4][2].