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Capillary Basement Membrane (CBM)
- Target
- CBM
- Molecular classification
- Extracellular Matrix, Basement Membrane
01
Overview
The capillary basement membrane is a specialized, thin layer of extracellular matrix that underlies and supports the endothelial cells lining capillaries. It plays critical roles in structural support, selective permeability, cell signaling, and tissue compartmentalization. It consists mainly of laminins, type IV collagen isoforms, nidogens, and heparan sulfate proteoglycans (HSPGs).
02
Biological functions
Structural supportSelective permeabilityBarrier functionCell signalingAngiogenesis regulationTissue compartmentalization
03
Disease associations
Diabetic microangiopathyAlport syndromeTumor metastasisKidney diseaseBlood-brain barrier disruption
04
Safety considerations
Thickening of basement membraneBreaching of basement membrane during metastasisGenetic defects affecting basement membrane components
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