Molecular Classification
Extracellular Matrix, Basement Membrane
Disease Roles
Diabetic microangiopathyAlport syndromeTumor metastasis

Capillary Basement Membrane Overview

The capillary basement membrane is a specialized, thin layer of extracellular matrix that underlies and supports the endothelial cells lining capillaries. It plays critical roles in structural support, selective permeability, cell signaling, and tissue compartmentalization. It consists mainly of laminins, type IV collagen isoforms, nidogens, and heparan sulfate proteoglycans (HSPGs).

Mechanism of Action

Biological Functions

Structural support
Selective permeability
Barrier function
Cell signaling
Angiogenesis regulation
Tissue compartmentalization

Disease Associations

Diabetic microangiopathy
Alport syndrome
Tumor metastasis
Kidney disease
Blood-brain barrier disruption

Safety Considerations

  • Thickening of basement membrane
  • Breaching of basement membrane during metastasis
  • Genetic defects affecting basement membrane components