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Capillary lamina of choroid

Molecular classification
Other (specialized vascular tissue)
01

Overview

The **choriocapillaris**—also known as the **capillary lamina of the choroid**—is a specialized layer of fenestrated capillaries forming the innermost part of the choroid in the eye. It lies immediately adjacent to Bruch’s membrane and is characterized by a dense network of large-caliber vessels with high permeability. The primary function is to supply nutrients and oxygen to—and remove waste from—the outer retina, particularly photoreceptors and retinal pigment epithelium. The structure is essential for maintaining normal vision; its loss or dysfunction plays a central role in age-related macular degeneration and other retinochoroidal diseases. The choriocapillaris itself is not a molecular target such as an enzyme or receptor but rather an anatomical microvascular structure; thus it does not have direct drug interactions or mechanisms typical for therapeutic targets. **Note:** This entry is marked *is_incorrect = true* because "Choriocapillaris" refers to an anatomical vascular network—not a single molecule/receptor/therapeutic target. It cannot be classified under standard molecular target categories like receptor, enzyme, transporter, etc.

Other names
Choriocapillarischoriocapillary layercapillary layer of the choroid
02

Biological functions

Nourishment of photoreceptors and retinal pigment epitheliumRemoval of metabolic waste from the outer retina
03

Disease associations

Age-related macular degeneration (AMD)Retinochoroidal diseases (including vascular and inflammatory diseases, myopia, pachychoroid spectrum disorders, glaucoma)
04

Safety considerations

Loss or dysfunction can lead to vision-threatening conditions such as AMD
05

Biomarkers

Imaging-based biomarkers for AMD progression (e.g., OCT angiography signal voids)

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