Capillary Permeability Modulation

Capillary permeability refers to the property of blood capillary endothelium that allows for the selective exchange of substances between the blood and surrounding tissues. The modulation of capillary permeability involves dynamic changes in how easily substances can pass through or between endothelial cells lining the capillaries. This process is essential for maintaining tissue homeostasis, nutrient delivery, waste removal, and immune surveillance. Key mechanisms include endothelial junctions, transcellular pathways, ion channels (e.g., TRP channels), and albumin interaction. Modulators include calcium signaling, inflammatory mediators (e.g., histamine, bradykinin, VEGF), and GPCR pathways. Dysregulation is implicated in various pathologies, offering potential therapeutic targets for edema-associated diseases and drug delivery enhancement.

Other names

Vascular PermeabilityEndothelial PermeabilityBlood-Tissue Barrier Permeability