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Target intelligence / Profile preview
Capillary Wall
- Molecular classification
- Cellular Structure, Tissue Barrier
01
Overview
The capillary wall is the thin cellular barrier forming the boundary of capillaries, the smallest blood vessels. Composed primarily of a single layer of endothelial cells and a basement membrane, its structure facilitates the bidirectional exchange of gases, nutrients, and waste between the blood and surrounding tissues. Its permeability is tightly regulated and its dysfunction is implicated in a wide range of diseases.
- Other names
- Capillary endotheliumMicrovascular wallBlood vessel wall (capillary)Capillary membrane
02
Mechanism of action
N/A
03
Biological functions
Selective permeabilityNutrient exchangeWaste removalGas exchangeRegulation of blood flowBarrier function
04
Disease associations
EdemaVascular leakInflammationDiabetic microangiopathyBlood-brain barrier disruptionSepsisCancer metastasis
05
Safety considerations
Increased permeability leading to edemaCompromised barrier functionThrombosisUncontrolled angiogenesisDrug delivery limitations due to BBB
06
Interacting drugs
Vasoconstrictors
5 more in the full profile.
07
Biomarkers
Circulating endothelial cellsAngiopoietin-2VEGFMarkers of inflammation (e.g., cytokines)Albuminuria
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