Gosset Molecular Classification
Cellular Structure, Tissue Barrier
Other Names
Capillary endothelium, Microvascular wall, Blood vessel wall (capillary), Capillary membrane
Disease Roles
Capillary Wall Overview
The capillary wall is the thin cellular barrier forming the boundary of capillaries, the smallest blood vessels. Composed primarily of a single layer of endothelial cells and a basement membrane, its structure facilitates the bidirectional exchange of gases, nutrients, and waste between the blood and surrounding tissues. Its permeability is tightly regulated and its dysfunction is implicated in a wide range of diseases.
Mechanism of Action
N/A
Biological Functions
Selective permeability
Nutrient exchange
Waste removal
Gas exchange
Regulation of blood flow
Barrier function
Disease Associations
Edema
Vascular leak
Inflammation
Diabetic microangiopathy
Blood-brain barrier disruption
Sepsis
Cancer metastasis
Safety Considerations
- Increased permeability leading to edema
- Compromised barrier function
- Thrombosis
- Uncontrolled angiogenesis
- Drug delivery limitations due to BBB
Interacting Drugs
Vasoconstrictors
Vasodilators
Anti-inflammatory agents
Angiogenesis inhibitors
Permeability-enhancing agents
Corticosteroids
Associated Biomarkers
| Biomarker |
|---|
| Circulating endothelial cells |
| Angiopoietin-2 |
| VEGF |
| Markers of inflammation (e.g., cytokines) |
| Albuminuria |