Caprin family member 2 (CAPRIN2)

Caprin family member 2 (CAPRIN2) is a multifunctional cytoplasmic protein acting primarily as an RNA-binding and scaffolding molecule. It plays a pivotal role in the regulation of the canonical Wnt/β-catenin signaling pathway by facilitating phosphorylation of the Wnt co-receptors LRP5/6, which stabilizes β-catenin and activates Wnt target gene transcription[1][7]. CAPRIN2 functions are highly context-dependent and include regulation of cell proliferation, differentiation (especially in erythroblasts and lens fiber cells), and involvement in tissue-specific developmental processes[1][4][6]. Structurally, CAPRIN2 carries homologous domains with its family member Caprin-1, and forms homodimers via its HR1 domain[3][7], potentially mediating formation of specialized ribonucleoprotein complexes. In the brain, CAPRIN2 regulates mRNA stability and plasticity in hypothalamic neurons, critically mediating responses to osmotic challenges and influencing vasopressin transcript abundance and modification[2][5]. Its dysregulation has been linked to developmental defects, cancer progression, multidrug resistance, and altered physiological homeostasis, but it currently lacks direct pharmacological modulation.

Other names

Caprin-2C1QDC1EEG1KIAA1873RNG140C1q domain-containing protein 1Cytoplasmic activation/proliferation-associated protein 2Gastric cancer multidrug resistance-associated proteinProtein EEG-1RNA granule protein 140FLJ22569FLJ11391

Null. No drugs are known to act directly on CAPRIN2. Mechanism of regulatory action is via protein-protein interactions and RNA binding rather than direct pharmacological modulation