CAPS2 antisense RNA 1 (CAPS2-AS1)

CAPS2 antisense RNA 1 (CAPS2-AS1) is a long non-coding RNA transcribed from the antisense strand of the genomic locus neighboring the CAPS2 gene[3]. Antisense RNAs, particularly lncRNAs like CAPS2-AS1, function mainly in regulation of gene expression by interacting with sense transcripts or modulating chromatin state at their loci of origin or distant genomic regions[1]. These RNAs do not encode functional proteins, and their regulatory effects may be mediated via several mechanisms including transcriptional interference, RNA-DNA interactions, and recruitment of chromatin modifiers. While many antisense lncRNAs play roles in cancer and other diseases, there is no disease-specific or drug interaction data for CAPS2-AS1 currently available[3][1]. CAPS2-AS1 should not be confused with the CAPS2 (Calcium-dependent activator protein for secretion 2) protein, which is involved in neurosecretion[4]; CAPS2-AS1 itself does not encode a protein and is not a receptor or enzyme. Antisense lncRNAs as a class are of growing interest in epigenetic gene regulation and as potential (but largely exploratory) therapeutic targets; however, CAPS2-AS1 currently has no established therapeutic or diagnostic use[3][1].

Other names

LOC100130268CAPS2-AS1