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Capsid protein (CA)–Spacer Peptide 1 (SP1) cleavage site (CA-SP1 cleavage site)
- Target
- CA-SP1 cleavage site
- Molecular classification
- Viral protein cleavage site, HIV-1 Gag polyprotein region
01
Overview
The CA–SP1 cleavage site is a specific region within the HIV-1 Gag polyprotein, located between the capsid protein (CA) and spacer peptide 1 (SP1). This site is crucial for viral maturation, as it is the target of the final proteolytic cleavage by the viral protease during HIV-1 particle maturation. Cleavage at this site triggers a major structural rearrangement essential for infectivity, making it an attractive target for maturation inhibitors.
- Other names
- CA/SP1 junctionCapsid-SP1 cleavage siteHIV CA-SP1 cleavage siteGag CA-SP1 cleavage site
02
Mechanism of action
Stabilization of the CA-SP1 six-helix bundle, preventing HIV protease access and blocking cleavage at the CA-SP1 junction.
03
Biological functions
HIV-1 maturationCapsid formationViral infectivity
04
Disease associations
HIV-1 infection
05
Safety considerations
Resistance mutationsDrug resistance
06
Interacting drugs
Bevirimat
2 more in the full profile.
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