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Capsid-Spacer Peptide 1 Region of Gag Protein (CA-SP1)
- Target
- CA-SP1
- Molecular classification
- Viral Protein, Gag Polyprotein Subunit, Peptide
01
Overview
The capsid-spacer peptide 1 (CA-SP1) region is a critical segment within the Gag polyprotein of retroviruses, most notably HIV-1. The Gag polyprotein is essential for viral assembly and maturation, and its proper processing by the viral protease is required for infectivity. The CA-SP1 region specifically refers to the junction between the capsid (CA, p24) domain and spacer peptide 1 (SP1), a short sequence that plays a pivotal role in virus particle formation and maturation. It is essential for correct virion assembly and morphological transition during budding/maturation. Small molecules like bevirimat inhibit HIV replication by blocking cleavage at CA-SP1. This prevents proper core condensation and halts virus maturation—making it an attractive antiviral target.
- Other names
- CA-SP1 JunctionCapsid-SP1 RegionGag CA-SP1p24-SP1
02
Mechanism of action
Inhibition of HIV-1 protease cleavage at the CA-SP1 junction, preventing proper core condensation and maturation.
03
Biological functions
Virion AssemblyVirion MaturationCore CondensationHIV-1 Replication
04
Disease associations
InfectionHIV-1 Infection
05
Safety considerations
Drug resistance development due to mutations in the CA-SP1 region.Potential for off-target effects due to structural similarity with host proteins.
06
Interacting drugs
Bevirimat
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