Capsular polysaccharide of Streptococcus pneumoniae serotype 19F (CPS19F)

The capsular polysaccharide of Streptococcus pneumoniae serotype 19F is a complex carbohydrate structure that forms the outermost layer of the bacterium. It is composed of repeating units of [→4)-β-D-Glcp-(1→4)-α-L-Rhap-(1→4)-α-D-Glcp-(1-PO4→], which provides a physical barrier against the host's immune system, specifically preventing opsonization and subsequent phagocytosis by macrophages and neutrophils (Source: PubMed, PMID: 15501010). As a primary virulence factor, it allows the pathogen to survive in the bloodstream and mucosal surfaces, leading to invasive pneumococcal diseases such as pneumonia, meningitis, and sepsis, as well as non-invasive conditions like otitis media (Source: CDC, Pink Book). In the context of pharmacology, this polysaccharide serves as a critical antigen in both pneumococcal conjugate vaccines (PCVs) and pneumococcal polysaccharide vaccines (PPSVs). These vaccines work by stimulating the production of B-cells and high-affinity antibodies that recognize the 19F structure, thereby neutralizing the bacteria and promoting its clearance through the immune system (Source: FDA, Prevnar 20 Package Insert).

Other names

Pneumococcal polysaccharide serotype 19FStreptococcus pneumoniae type 19F capsular polysaccharideS. pneumoniae serotype 19F CPSType 19F capsular polysaccharide

Induction of serotype-specific opsonophagocytic antibodies that facilitate bacterial clearance by the immune system.