Carbohydrate substrates for short-chain fatty acid production by Lactoplantibacillus plantarum CECT7528

Carbohydrate substrates for short-chain fatty acid production by Lactoplantibacillus plantarum CECT7528 refers to the group of fermentable dietary fibers and prebiotics utilized by this specific probiotic strain to generate bioactive metabolic byproducts (Fuentes et al., 2013, British Journal of Nutrition). Lactoplantibacillus plantarum CECT7528 (formerly Lactobacillus plantarum) is a well-characterized probiotic strain known for its ability to survive gastrointestinal transit and modulate host health, particularly regarding lipid metabolism and gut homeostasis. The primary substrates include complex polysaccharides like inulin and fructo-oligosaccharides (FOS), which the bacteria ferment into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. These SCFAs act as signaling molecules that interact with host receptors to regulate inflammation, maintain intestinal barrier integrity, and influence energy expenditure. While not a single molecular target, these substrates are essential components of synbiotic therapies designed to address dysbiosis, hypercholesterolemia, and inflammatory bowel conditions. The efficacy of these substrates depends on the metabolic capacity of the CECT7528 strain to convert them into metabolites that influence the host's physiological state (Espadaler et al., 2012, Drug Healthcare and Patient Safety).

Other names

Prebiotics for Lactoplantibacillus plantarum CECT7528Fermentable dietary fibersShort-chain fatty acid precursorsL. plantarum CECT7528 substrates

Bacterial fermentation of non-digestible carbohydrates into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, which subsequently modulate host physiology via G protein-coupled receptors like GPR41 and GPR43 (Gibson et al., 2017, Nature Reviews Gastroenterology & Hepatology).