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Target intelligence / Profile preview
Carbohydrate Sulfotransferase 15 (CHST15)
- Target
- CHST15
- Molecular classification
- Enzyme, Sulfotransferase, Type II transmembrane protein
01
Overview
Carbohydrate sulfotransferase 15 (CHST15) is a type II transmembrane Golgi enzyme that catalyzes the transfer of sulfate to N-acetylgalactosamine 4-sulfate (GalNAc4S) on chondroitin sulfate, generating chondroitin sulfate E (CS-E). It plays a critical role in modulating fibrogenesis, inflammation, and tumorigenesis, making it a potential therapeutic target for fibrotic diseases and cancer. Its expression is upregulated in various pathological conditions, including cardiac and intestinal fibrosis, and esophageal squamous cell carcinoma.
- Other names
- GalNAc4S-6STBRAGB-cell RAG-associated proteinN-acetylgalactosamine 4-O-sulfate 6-O-sulfotransferase
02
Mechanism of action
Blockade or silencing of CHST15 to reduce chondroitin sulfate E (CS-E) production, thereby modulating fibrotic and inflammatory pathways.
03
Biological functions
Sulfation of chondroitin sulfateRegulation of fibrosisModulation of inflammationRegulation of cell differentiationRegulation of morphogenesisBinding growth factors
04
Disease associations
Cardiac fibrosisIntestinal fibrosisEsophageal squamous cell carcinomaInflammationViral infection
05
Safety considerations
Potential off-target effects of CHST15 inhibitorsLong-term consequences of altered chondroitin sulfate sulfation patternsSpecificity of siRNA delivery to target tissues
06
Interacting drugs
siRNA (targeting CHST15)
2 more in the full profile.
07
Biomarkers
CHST15 expression levelsCS-E levels
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