Carbohydrate sulfotransferase 5 (CHST5)

Carbohydrate sulfotransferase 5 (CHST5) is a type II Golgi-localized membrane enzyme that transfers a sulfate group from the donor molecule 3'-phospho-5'-adenylyl sulfate (PAPS) to the 6-O position of galactose, N-acetylgalactosamine, or N-acetylglucosamine residues on proteoglycans and glycoproteins[1][2][4][6]. This sulfation reaction modifies the structural properties of mucins and other carbohydrates, which can affect their recognition by extracellular matrix proteins, receptors, and viruses and influence biological processes such as cell-cell communication, mucosal barrier function, and immune modulation[2]. CHST5 is predominantly expressed in intestinal tissues such as the colon and small intestine[1][2][6]. Its altered expression and function have been studied in the context of neurodegenerative diseases (notably Alzheimer's disease) and gastrointestinal tract physiology, but there are no approved drugs targeting CHST5 nor definitive clinical safety concerns currently reported[1][6].

Other names

I-GlcNAc-6-STI-GlcNAc6STglcNAc6ST-3gn6st-3hIGn6STGlcNAc6ST-3GST4-alphaN-acetylglucosamine 6-O-sulfotransferase 3intestinal GlcNAc-6-sulfotransferaseFLJ22167galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha