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Carbon Monoxide Release
- Molecular classification
- Gasotransmitter, Signaling molecule
01
Overview
Carbon monoxide (CO) is a small, endogenously produced gas that acts as a signaling molecule in the human body. It is primarily generated through the enzymatic degradation of heme by heme oxygenase enzymes. At low physiological levels it plays important roles in vasoregulation and inflammation modulation. CO exerts vasodilatory effects mainly via activation of soluble guanylate cyclase (sGC) and opening potassium channels. The anti-inflammatory effects are attributed to modulation of inflammatory cell signaling and downregulation of pro-inflammatory cytokines. Therapeutic delivery is achieved via Carbon Monoxide-Releasing Molecules (CORMs), compounds that release controlled amounts of CO.
- Other names
- CO releaseCarbon monoxide-releasing moleculesCORMs
02
Mechanism of action
Activation of soluble guanylate cyclase (sGC); Opening potassium channels; Modulation of inflammatory cell signaling; Downregulation of pro-inflammatory cytokines
03
Biological functions
VasodilationInflammation reductionCytoprotectionSignal transduction
04
Disease associations
Cardiovascular diseaseInflammationIschemia/reperfusion injury
05
Safety considerations
Potential for systemic toxicityOver-vasodilationPro-oxidant effects under certain conditions
06
Interacting drugs
Carbon Monoxide-Releasing Molecules (CORMs)
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