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Target intelligence / Profile preview
Carbonic Anhydrase 1 (CA1)
- Target
- CA1
- Molecular classification
- Enzyme, Carbonic Anhydrase, Alpha-carbonic anhydrase
01
Overview
Carbonic anhydrase 1 (CA1) is a cytosolic enzyme belonging to the alpha-carbonic anhydrase subfamily. It plays a crucial role in cellular pH regulation and CO2 transport. CA1 is highly expressed in red blood cells and has been implicated in cardiovascular complications of diabetes, as well as ocular diseases. Its dysregulation contributes directly to several disease states including cardiovascular complications from diabetes as well as ocular diseases involving vascular leakage.
02
Mechanism of action
Catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons.
03
Biological functions
CO2 hydrationBicarbonate productionpH regulationAcid-base balanceCO2 transport
04
Disease associations
Diabetic cardiomyopathyIschemic heart diseaseDiabetic retinopathyMacular edemaProstate cancer
05
Safety considerations
Relatively low affinity for common carbonic anhydrase inhibitors may limit drug efficacy.Off-target effects on other carbonic anhydrase isoforms.
06
Interacting drugs
Coumarins
6 more in the full profile.
07
Biomarkers
CA1 expression levels in myocardial tissue (for diabetic cardiomyopathy)CA1 expression levels in vascular endothelium (for retinopathy)
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