Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Carbonic Anhydrase 14 (None)
- Target
- None
- Molecular classification
- Enzyme, Type I membrane protein, Metalloprotein
01
Overview
Carbonic anhydrase 14 (CA14) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide. It is a type I membrane protein highly expressed in the central nervous system, with lower expression in other tissues such as liver, heart, and kidney. As a member of the carbonic anhydrase family, it plays a role in respiration, acid-base balance, and fluid secretion. CA14 is considered a potential drug target due to its role in pH regulation, and inhibitors have been identified.
- Other names
- CA XIVCAXIVcarbonic anhydrase XIVCar14
02
Mechanism of action
Inhibition of enzymatic activity, blocking the reversible hydration of carbon dioxide.
03
Biological functions
Catalysis of carbon dioxide hydrationRespirationAcid-base homeostasisFluid secretionpH regulation
04
Disease associations
Potential role in neurological disorders (inferred from CNS expression)Potential role in cancer (inferred from melanocytic regulation)Other (diseases related to electrolyte balance/fluid secretion)
05
Safety considerations
Off-target effects due to structural similarity to other carbonic anhydrasesPotential disruption of normal pH balance
Beyond the preview
Go deeper on Carbonic Anhydrase 14 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Carbonic Anhydrase 14 (None).