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Target intelligence / Profile preview
Carbonic Anhydrase 14
- Molecular classification
- Enzyme, Type I membrane protein, Metalloprotein
01
Overview
Carbonic anhydrase 14 (CA14) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide. It is a type I membrane protein highly expressed in the central nervous system, with lower expression in other tissues such as liver, heart, and kidney. As a member of the carbonic anhydrase family, it plays a role in respiration, acid-base balance, and fluid secretion. CA14 is considered a potential drug target due to its role in pH regulation, and inhibitors have been identified.
- Other names
- CA XIVCAXIVcarbonic anhydrase XIVCar14
02
Mechanism of action
Inhibition of enzymatic activity, blocking the reversible hydration of carbon dioxide.
03
Biological functions
Catalysis of carbon dioxide hydrationRespirationAcid-base homeostasisFluid secretionpH regulation
04
Disease associations
Potential role in neurological disorders (inferred from CNS expression)Potential role in cancer (inferred from melanocytic regulation)Other (diseases related to electrolyte balance/fluid secretion)
05
Safety considerations
Off-target effects due to structural similarity to other carbonic anhydrasesPotential disruption of normal pH balance
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