Carbonic anhydrase 14 pseudogene 1 (CA14P1)

CA14P1 is a human pseudogene related to carbonic anhydrase XIV (CA14). Pseudogenes are genomic DNA sequences similar to normal genes but are non-functional; they do not encode an active protein or produce enzyme activity[3]. While CA14 is a membrane-associated, zinc-containing enzyme involved in the reversible hydration of carbon dioxide and acid-base balance, CA14P1 does not encode a functional enzyme, does not participate in biological processes, and is not considered a druggable or therapeutic target[3]. There are no known disease associations, drugs, or mechanisms of action linked to CA14P1. Note: There is often confusion between CA14P1 (a pseudogene, not functionally expressed) and CA14, the bona fide carbonic anhydrase XIV enzyme[1][2][3][5]. The functional enzyme (CA14), not the pseudogene, is the protein coding gene involved in physiological processes and is sometimes a research target for carbonic anhydrase inhibitors. CA14P1 itself is not considered a therapeutic target and has no active biological or pharmacological role. If you are interested in the functional enzyme CA14, please clarify, as the properties and relevance differ significantly from its pseudogene form.

Other names

CA14P1carbonic anhydrase XIV pseudogenecarbonic anhydrase 14 pseudogeneCA14 pseudogene 1