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Target intelligence / Profile preview
Carbonic Anhydrase 2 (CA2)
- Target
- CA2
- Molecular classification
- Enzyme, Metalloprotein, Carbonic Anhydrase
01
Overview
Carbonic anhydrase 2 (CA2), also known as carbonic anhydrase II, is a zinc-containing metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and a proton, playing a crucial role in physiological processes such as respiration, pH regulation, ion transport, and bone resorption.
- Other names
- CAIICar2Carbonic anhydrase CCarbonate dehydratase IICAC
02
Mechanism of action
The enzyme uses its zinc-bound hydroxide for nucleophilic attack on CO₂ to form bicarbonate; this is then exchanged for water. A subsequent proton transfer regenerates the active site hydroxide via solvent exchange—a classic ping-pong mechanism.
03
Biological functions
CatalysisRegulation of pHCarbon dioxide transportBicarbonate transportBone resorptionAcid-base balance maintenance
04
Disease associations
OsteopetrosisRenal tubular acidosisGlaucomaEssential hypertensionHeart failureInsomniaSeborrhoeic dermatitisBacterial infections
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