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Target intelligence / Profile preview
Carbonic Anhydrase 3 (CA3)
- Target
- CA3
- Molecular classification
- Enzyme, Metalloprotein
01
Overview
Carbonic anhydrase 3 (CA3) is a cytosolic enzyme that belongs to the carbonic anhydrase family. It catalyzes the reversible hydration of carbon dioxide and is involved in pH regulation and CO2 transport. CA3 is highly expressed in skeletal muscle, liver, adipocytes, and other tissues. It is distinguished by its relatively low catalytic activity compared to other carbonic anhydrase isoforms and is linked to autoimmune disorders and protective responses to oxidative stress.
- Other names
- CAIIICar3Carbonic Anhydrase III
02
Mechanism of action
N/A
03
Biological functions
Catalysis of reversible hydration of CO2pH regulationCO2 transportPossible role in fatty acid metabolismRegulation during oxidative stress
04
Disease associations
Myasthenia GravisDuchenne Muscular DystrophyRheumatoid ArthritisSystemic Lupus Erythematosus (SLE)Type 1 Diabetes Mellitus
05
Safety considerations
Low catalytic activity limits its primary therapeutic value.Selectively targeting CA3 without affecting other CA isoforms is challenging.
06
Biomarkers
Autoantibodies against CAIII in autoimmune diseases
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