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Target intelligence / Profile preview
Carbonic Anhydrase from Schistosoma mansoni (SmCA/SmaBCA)
- Target
- SmCA/SmaBCA
- Molecular classification
- Enzyme, Metalloprotein, Carbonic Anhydrase, α-carbonic anhydrase, β-carbonic anhydrase
01
Overview
Carbonic anhydrases (CAs) are metalloenzymes that catalyze the reversible hydration of carbon dioxide. In *Schistosoma mansoni*, a parasitic blood fluke responsible for intestinal schistosomiasis, two classes of CAs have been identified: an α-class CA (SmCA) and a β-class CA (SmaBCA). These enzymes are essential for parasite survival and infectivity. SmCA is highly expressed in the tegument of *S. mansoni* and contributes to pH regulation, ion transport, and evasion of host immune responses. Inhibition of SmCA and SmaBCA is a promising therapeutic strategy for schistosomiasis.
- Other names
- SmCASmaBCASchistosoma mansoni Carbonic Anhydrase
02
Mechanism of action
Enzyme inhibition; Competitive inhibition of carbonic anhydrase activity
03
Biological functions
CO₂/bicarbonate conversionpH regulationIon transportImmune evasion
04
Disease associations
InfectionSchistosomiasis
05
Safety considerations
Potential for off-target effects on human carbonic anhydrasesDevelopment of resistance
06
Interacting drugs
Sulfonamides
2 more in the full profile.
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