Target intelligence / Profile preview

Carbonic Anhydrase I (CA I)

Target: CA I
Molecular classification: Enzyme, Metalloprotein, Carbonic Anhydrase, Lyase

Overview

Carbonic anhydrase I (CA I) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and protons (H+). This reaction is fundamental for maintaining acid-base balance and facilitating CO2 transport. CA I is a member of the alpha class of carbonic anhydrases and is found primarily in erythrocytes. Inhibitors of CA I, such as acetazolamide, are used therapeutically to treat conditions like glaucoma.

Mechanism of action

Inhibition of carbonic anhydrase activity, reducing bicarbonate formation and proton production.

Biological functions

Acid-base balanceCO2 transportRespirationpH regulation

Disease associations

GlaucomaEpilepsyAltitude sickness

Interacting drugs

Acetazolamide

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