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Target intelligence / Profile preview
Carbonic Anhydrase II Isoenzyme (CA II)
- Target
- CA II
- Molecular classification
- Enzyme, Hydrolase, Metalloenzyme
01
Overview
Carbonic anhydrase II (CA II) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide. It is crucial for pH regulation, respiration, ion transport, and acid-base balance in tissues. CA II plays key roles in renal bicarbonate reabsorption, bone resorption, and central nervous system pH homeostasis. Deficiency or mutations can cause osteopetrosis with renal tubular acidosis. It is a therapeutic target for conditions like glaucoma, where inhibition reduces intraocular pressure.
- Other names
- Carbonate dehydratase IICarbonic anhydrase 2CA2
02
Mechanism of action
Inhibition of carbonic anhydrase activity, reducing bicarbonate production and affecting fluid secretion/pH control.
03
Biological functions
Catalysis of CO2 hydration/dehydrationpH regulationRespirationIon transportAcid-base balanceRenal bicarbonate reabsorptionBone resorptionCentral nervous system pH homeostasis
04
Disease associations
Osteopetrosis with renal tubular acidosisGlaucomaEpilepsyAltitude sickness
05
Safety considerations
Systemic acidosisRenal calcificationsMental retardation (in untreated osteopetrosis with RTA)Electrolyte imbalances
06
Interacting drugs
Acetazolamide
2 more in the full profile.
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