Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Carbonic anhydrase-related protein 10 (CA10)
- Target
- CA10
- Molecular classification
- Catalytically inactive carbonic anhydrase homolog (α-carbonic anhydrase family) [1][3][4], Secreted glycoprotein, Cell adhesion molecule interacting protein
01
Overview
Carbonic anhydrase-related protein 10 (CA10) is a secreted, catalytically inactive member of the α-carbonic anhydrase family predominantly expressed in the central nervous system[1][3]. CA10 lacks the enzymatic activity typical of carbonic anhydrases due to the loss of key zinc-coordinating histidine residues[1][3]. It functions mainly as a binding partner for neurexins, a class of synaptic cell-adhesion molecules, and participates in modulating surface localization and trafficking of neurexins in neurons[1]. CA10 is evolutionarily conserved and may act as a molecular chaperone or as an adaptor enabling the assembly of synaptic protein complexes in the brain[1]. In addition, CA10 has been identified as a tumor suppressor with its gene methylation associated with patient prognosis in renal cell carcinoma[2].
- Other names
- CA10hucep-15UNQ533/PRO1076CA-RP XCARP XCARPXCA-RPXHUCEP-15Carbonic anhydrase-related protein XCerebral protein 15carbonic anhydrase Xcerebral protein-15epididymis secretory sperm binding protein
02
Biological functions
Acts as a binding partner for neurexins in the brain [1]Possible role as a chaperone for neurexin folding and trafficking in the secretory pathway [1]May function as an adaptor for formation of transsynaptic protein complexes [1]Does not have classic carbonic anhydrase catalytic activity [1][3]
03
Disease associations
Tumor suppressor in renal cell carcinoma [2]Implicated in neuropsychiatric disorders via linkage with neurexin complexes [1]
04
Biomarkers
CA10 methylation as a prognostic biomarker in renal cell carcinoma [2]
Beyond the preview
Go deeper on Carbonic anhydrase-related protein 10 (CA10).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Carbonic anhydrase-related protein 10 (CA10).