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Target intelligence / Profile preview
Carbonic anhydrase type II (CA II)
- Target
- CA II
- Molecular classification
- Enzyme, Metalloprotein, Carbonic Anhydrase
01
Overview
Carbonic anhydrase type II (CA II) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. It plays a crucial role in pH regulation and CO₂ transport in various tissues. Deficiency or mutations in CA II are associated with carbonic anhydrase II deficiency syndrome, characterized by osteopetrosis, renal tubular acidosis, and cerebral calcification. CA II is also a therapeutic target in glaucoma, hypertension, and other diseases.
02
Mechanism of action
Inhibition of carbonic anhydrase activity
03
Biological functions
Regulation of acid-base balanceCarbon dioxide transportBicarbonate reabsorptionBone resorptionFluid secretion
04
Disease associations
OsteopetrosisRenal tubular acidosisCerebral calcificationGlaucomaEssential hypertensionHeart failureInsomniaSeborrhoeic dermatitisBacterial infections
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