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Target intelligence / Profile preview
Carbonyl Reductase 1 (CBR1)
- Target
- CBR1
- Molecular classification
- Enzyme, Short-chain dehydrogenases/reductases (SDRs), Oxidoreductase
01
Overview
Carbonyl reductase 1 (CBR1) is an enzyme that catalyzes the reduction of a wide variety of carbonyl-containing compounds, including quinones, prostaglandins, menadione, and various xenobiotics. It plays a crucial role in protecting cells from oxidative stress, regulating glucocorticoid metabolism, and metabolizing clinically relevant drugs like doxorubicin. Genetic variations and altered expression of CBR1 can impact individual responses to medications and susceptibility to adverse effects.
- Other names
- CBRSDR21C1hcarbonyl reductase 1PG-9-KR
02
Mechanism of action
Reduces pharmacologically active ketones/aldehydes
03
Biological functions
Reduction of carbonyl compoundsDetoxification of xenobioticsProtection against oxidative stressGlucocorticoid metabolism regulation
04
Disease associations
Drug toxicityMetabolic diseases (diabetes/obesity)Neurodegenerative diseasesIschemic brain injury
05
Safety considerations
Variations in drug efficacy and toxicity due to genetic polymorphismsPotential for drug-drug interactions affecting CBR1 activity
06
Interacting drugs
Doxorubicin
3 more in the full profile.
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