Carboxylesterase 1 pseudogene 2 (CES1P2)

**Carboxylesterase 1 pseudogene 2 (CES1P2)** is a genomic sequence similar to the carboxylesterase 1 (CES1) gene and classified as a pseudogene[2]. Pseudogenes typically arise from gene duplication or retrotransposition and do not encode active proteins. CES1P2 shares sequence similarity with CES1, which is an enzyme critical to phase I drug metabolism, particularly in the liver; however, CES1P2 itself is not translated into a protein and has no demonstrated direct function in drug metabolism or disease pathways. Some regulatory effects of CES family pseudogenes on gene expression have been described for CES1P1, but CES1P2 does not have confirmed functional or clinical significance as a therapeutic target[2][4][5]. **Notes:** - **CES1, not CES1P2, is the active carboxylesterase enzyme linked to drug metabolism, clinical pharmacogenetics, and biomarker research[1][3][5].** - CES1P2 may sometimes be referenced in genomic studies, but current data indicate it is *not* a target for pharmacological intervention, nor clinically relevant outside research contexts.

Other names

CES1P2Carboxylesterase 1 pseudogene 2