Carboxylesterase 1d (Ces1d (mouse); sometimes CES1D is used in literature)

Carboxylesterase 1d (Ces1d) is a member of the carboxylesterase family of enzymes found predominantly in mouse liver, lung, and adipose tissue[4][5]. It belongs to the serine hydrolase superfamily and regulates hydrolysis of neutral lipids such as triacylglycerols and cholesterol esters, as well as xenobiotic esters and amides[6]. Ces1d is essential for intracellular lipid and cholesterol homeostasis and is a major metabolic enzyme in lung and liver tissues, especially alveolar macrophages[5]. It is involved in the breakdown of lipid mediators and participates in immune regulation, being a target of organophosphate toxins. While the exact role of Ces1d in cholesterol ester hydrolysis remains debated, its knockout impairs regulation of inflammation and may disrupt cholesterol efflux in experimental models[6]. Ces1d is considered a key metabolic enzyme relevant for pharmacology, toxicology, and metabolic disease research in mice[5][6].

Other names

Ces1dCes1d proteinhepatic carboxylesteraseserine esterase 1d

Drug metabolism via hydrolysis of ester and amide bonds in drugs and prodrugs. Lipid hydrolysis (triacylglycerol, thioester, cholesterol ester metabolism). Regulation of lipid-derived signaling molecules, effect on immune cells.