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Target intelligence / Profile preview
Carboxylesterase 2 (CES2)
- Target
- CES2
- Molecular classification
- Enzyme, Hydrolase, Serine hydrolase, Alpha/beta fold hydrolase
01
Overview
Carboxylesterase 2 (CES2) is an enzyme primarily involved in the hydrolysis of ester and amide bonds. It plays a crucial role in drug and lipid metabolism, as well as detoxification. CES2 is highly expressed in the liver, intestine, and kidney and is implicated in various diseases, including NAFLD and certain cancers. Genetic polymorphisms in CES2 can affect drug response.
- Other names
- CE-2CES2A1PCE-2iCECES-2
02
Mechanism of action
Hydrolyzes ester and amide bonds in drugs and endogenous compounds, affecting their bioavailability and activity.
03
Biological functions
Hydrolysis of ester bondsHydrolysis of amide bondsDrug metabolismLipid metabolismDetoxification of xenobioticsRegulation of lipid signaling pathwaysEnergy homeostasis
04
Disease associations
Non-alcoholic fatty liver disease (NAFLD)Obesity-related hepatic steatosisAlveolar EchinococcosisNorth American Indian Childhood CirrhosisNon-Hodgkin lymphomaB-cell lymphocytic leukemia
05
Safety considerations
Variability in drug response due to genetic polymorphismsPotential for drug-drug interactions
06
Interacting drugs
Cocaine
2 more in the full profile.
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